Full presentation of the research team

The team “Organic Synthesis” is specialized in the study of the reactivity of organic compounds and multi-step synthesis of molecules with high added value. She has expertise in:

– the multi-step synthesis of complex organic molecules

– knowledge of the reaction mechanisms involved in these transformations

– spectroscopic characterization and structural elucidation of organic compounds

– chemical functionalization of natural products

– the extraction and exploitation of natural bioactive compounds

Organic Synthesis Team

This team develops unique skills declined along three axes of original research:

1) Axis “Glycochemistry”

Sugar chemistry or glycochemistry comprises coupling and / or functionalizing the sugar or the like to generate glycoconjugates. This is a burgeoning field. Indeed, the sugars are natural organic synthons available and inexpensive with multiple stereogenic centers. Processing using simple chemical reactions provides quick access to chiral complexes. In addition, because of highlighting the role of sugars in a growing number of biochemical processes, this family of molecules growing interest on the part of chemists and biologists to better understand their biological role and access to molecules therapeutic benefit derived from sugars.

In this context, this axis is particularly interested in:

  • the synthesis of sugar mimics (iminosugars, sugars forced) for therapeutic applications and mechanistic
  • the synthesis of oligosaccharides and glycoconjugates for therapeutic
  • the synthesis of modified cyclodextrins to generate new biomass objects possessing properties of molecular recognition and catalysis
  • synthesis and structural elucidation of natural products from chiral pool sugars

2) Axis “Synthesis in superacid medium”

The use of superacid media in organic synthesis is an original theme in France and very undeveloped in the world. The originality of this research lies in the ability to perform polyprotonation organic molecules in these environments, singular behavior compared to conventional acidic. The polyprotonation substrates provides access to reagents or reaction intermediates called polycationic superelectrophilic and develop new methodologies in organic synthesis that has no equivalent in organic chemistry “classic”. Research being developed by the group superacid revolve around the following themes: New methods of synthesis of fluorinated compounds Functionalization of unactivated connections Synthesis of nitrogen compounds (fluorinated) with biological activity

3) Axis “programmed molecular systems”

The design of molecular systems composed of separate units, which are coordinated to achieve a complex task represents a challenge in organic chemistry. Such systems include, within their structure a program that will determine their behavior in interaction with the external environment. In this context, our group has developed several research themes:

  • design molecular systems programmed for therapeutic targeting of anticancer agent
  • the development of artificial molecular machines
  • the study of systems consisting of a network of molecules

Specific equipment:

Analysis platform (400 MHz NMR, mass spectrometry, HPLC, polarimeter)
Purification systems automatic solvents
Automatic flash chromatography systems

Fields of application:

Therapy (oncology, epigenetics, orphan diseases)

Molecular recognition (ionophores, rotaxanes)

Vectorization

Green chemistry

Recherche

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