El artículo de Cladiu. T. Supuran y Sebastian Thibaudeau aparece en la cubierta de ChemComm, Julio 2013.

El comunicado de Claudiu. T. Supuran, Sébastien Thibaudeau y al. aparece en la cubierta de la revista ChemComm de Julio 2013.

El artículo se titula “New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors : toward a new mode of carbonic anhydrase inhibition by sulfonamides”.

Chem. Commun., 2013, 49, 5999-5999 DOI : 10.1039/C3CC90186F

Lien vers ChemComm

ChemComm July 2013

Resumen: Tertiary substituted (fluorinated) benzenesulfonamides were synthesized in superacid HF/SbF5 and tested as inhibitors of human carbonic anhydrases (hCAs, EC Strong selectivity toward tumor-associated hCA IX, without inhibiting the offtarget hCA II, was observed, pointing out to a new mechanism of action compared to classical sulfonamides


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