The article of Claudiu. T. Supuran and Sebastian Thibaudeau made the cover of ChemComm, July 2013

The article of Claudiu. T. Supuran, Sébastien Thibaudeau and al. made the cover of the magazine ChemComm in July 2013.

This article was entitled “New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors : toward a new mode of carbonic anhydrase inhibition by sulfonamides ».

Chem. Commun., 2013, 49, 5999-5999
DOI : 10.1039/C3CC90186F

Lien vers ChemComm

ChemComm July 2013

Abstract : Tertiary substituted (fluorinated) benzenesulfonamides were synthesized in superacid HF/SbF5 and tested as inhibitors of human carbonic anhydrases (hCAs, EC 4.2.1.1). Strong selectivity toward tumor-associated hCA IX, without inhibiting the offtarget hCA II, was observed, pointing out to a new mechanism of action compared to classical sulfonamides.

Congratulations to Organic Synthesis team.

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