BLERIOT Yves

Professor

Head of organic chemistry laboratory (12 chemists  + 15 PhD/post-docs/master)

Head of the glycochemistry group (5 chemists + 5 PhD + 1 master)

Bâtiment B28

Equipe Synthèse organique (E5)

IC2MP UMR 7285 – Université de Poitiers – UFR SFA

Bâtiment B28, TSA 51106

4 rue Michel Brunet

86073 Poitiers cedex 9

Tel : +33 (0)5.49 45 39 66

@ : yves.bleriot@univ-poitiers.fr

Education

  • 1994-1997:  Research Fellow (Pr Fleet)  Sugar lactones – Oxford University (UK)
  • 1990-1994: PhD (Pr. Tellier) Catalytic antibodies – Nantes University (F) 

Professional Employment

  • 2012: Head of Organic Chemistry Laboratory – Poitiers University
  • 2009: Professor – Poitiers University
  • 2007: Assistant Professor (Pr Malacria group) – Paris 6 University
  • 1997: Assistant Professor (Pr Sinaÿ group) – Ecole Normale Supérieure (ENS)

Résumé

  • 88 published papers in peer review international journals
  • H factor: 22; Number of citations:  1300 (Web of Science)
  • Invited Professor University of Guizhou (China) from 2007 to 2009
  • Member of the Scientific Committee of AFM-téléthon and French National Agency of Research (ANR)

Research area: GLYCOSCIENCES

  • Design of sugar analogs including iminosugars and locked sugars
  • Total synthesis of natural products from the chiral pool of sugars
  • Study of the glycosylation reaction
  • Synthesis of oligosaccharides for biological studies

Publications marquantes

  • Catching elusive glycosyl cations in a condensed phase using superacid, A. Martin, A. Arda, J. Désiré, J. Marrot, N. Probst, A. Mingot, P. Sinaÿ, S. Thibaudeau, Y. Blériot, Nature Chem. 2016, 8, 186-191
  • Site-directed hexa-hetero-functionalisation of an archetypic C6-symmetric concave cycle, a-cyclodextrin, Wang, E. Zaborova, S. Guieu, M. Petrillo, M. Guitet, Y. Blériot, M. Ménand, Y. Zhang, M. Sollogoub, 2014, Nature Commun. 5 :5354
  • Access to both L-and D-iminosugar C-glycosides from a D-gluco derived 6-azidolactol exploiting a ring isomerisation / alkylation strategy, M. Mondon, N. Fontelle, J. Désiré, F. Lecornué, J. Guillard, J. Marrot, Y. Blériot, Lett. 2012, 14, 870-873
  • Analysis of the reaction coordinate of a-L fucosidases: a combined structural and quantum mechanical approach, A. Lammerts van Bueren, J. Fayers-Kerr, B. Luo, Y. Zhang, M. Sollogoub, Y. Blériot, C. Rovire, G. J. Davies, Am. Chem. Soc. 2010, 132, 1804-1806
  • Inhibition of GH84 O-GlcNAcases by polyhydroxylated 3- and 4-acetamido azepanes : inhibitor flexibility enables to probe substrate distorsion, F. Marcelo, Y. He, S.A. Yuzwa, L. Nieto, J. Jiménez-Barbero, M. Sollogoub, D.J. Vocadlo, G.J. Davies, Y. Blériot, Am. Chem. Soc. 2009, 131, 5390-5392
  • Structural and biochemical evidence for a boat like transition state in b-mannosidases N. Tailford,  W. Offen, N. Smith, C. Dumon, C. Moreland, J. Gratien, M.-P. Heck, R.V. Stick, Y. Blériot, A. Vasella, H.J. Gilbert, G.J. Davies, Nature Chem. Biol. 2008, 4, 306-312