L’article de Claudiu. T. Supuran et Sébastien Thibaudeau fait la couverture de ChemComm de Juillet 2013.

La COMMUNICATION de Claudiu. T. Supuran, Sébastien Thibaudeau et al. fait la couverture de la revue ChemComm de juillet 2013.

L’article est intitué « New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides ».

Chem. Commun., 2013, 49, 5999-5999
DOI: 10.1039/C3CC90186F

Lien vers ChemComm

ChemComm July 2013

Abstract : Tertiary substituted (fluorinated) benzenesulfonamides were synthesized in superacid HF/SbF5 and tested as inhibitors of human carbonic anhydrases (hCAs, EC Strong selectivity toward tumor-associated hCA IX, without inhibiting the offtarget hCA II, was observed, pointing out to a new mechanism of action compared to classical sulfonamides.

Bravo à l’équipe Synthèse Organique.



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